FABRICATION OF POLY(LACTIC-CO-GLYCOLIC ACID)/CALCIUM PHOSPHATE BONE CEMENT COMPOSITE: SYNTHESIZATION OF CALCIUM PHOSPHATE FROM CRAB SHELLS

Mohammad Redzuan Abdul Hanan, Ahmad Kafrawi Nasution, Rafaqat Hussain, Syafiqah Saidin

Abstract


Crab shells are waste product, rich with calcium compound. Calcium element is often used as a material for bone scaffold due to its bioactive and biodegradation properties. In this study, calcium phosphate (CaP) nanoparticles were synthesized from crab shells through a wet chemical route. The CaP nanoparticles were then sintered and mixed with poly(lactic-co-glycolic acid) (PLGA) to form a bone cement composite. The mixture was casted in a cylinder shape and it was characterized through ATR-FTIR, XRD, FESEM, contact angle and DSC analyses. The CaP pellet and the CaP/PLGA bone cement composite were then subjected to in vitro simulated body fluid (SBF) bioactivity test. The CaP/PLGA bone cement composite was found to have a composition of crystal CaP and PLGA with a tolerable glass transition state, suitable to be used in a physiological environment. The CaP nanoparticles were agglomerated on the 3D interconnected surface of PLGA. The hydrophobicity of the CaP was increased (66.94%) with the addition of PLGA as a binder matrix where this composite has induced the formation of apatite layer. This bioactive property is crucial in fabricating a bone substitute material as it can promotes cell penetration, attachment and proliferation.

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Keywords


Bone cement, calcium phosphate, poly(lactic-co-glycolic acid), crab shells, bioactive

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References


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DOI: https://doi.org/10.11113/jt.v80.11525

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